Journal: Cancer biology & therapy

Article Title: The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer.

doi: 10.4161/cbt.6.6.4098

Figure Lengend Snippet: Figure 2. Expression values of four CRT-responsive genes evaluated by microarray in pretreatment (pre) and midtreatment (mid) samples. Normalized expression values are shown for CDKN1A, BAX, TNFSF8 and RRM2B in 19 CRT cases and 20 RT cases. The open circle indicates a patient with a p53 mutation. Significant upregu‑ lation of these genes was induced by CRT. RT-treated samples showed variation between patients in the change of expression of these genes.

Article Snippet: They were stained with Cy5‐streptavidin (Amersham Biosciences) and scanned using a dual‐laser microarray scanner (Agilent).

Techniques: Expressing, Microarray, Mutagenesis

Journal: Nature Biotechnology

Article Title: Chinese health biotech and the billion-patient market

doi: 10.1038/nbt0108-37

Figure Lengend Snippet: Chinese health biotech firms interviewed and their product/technology portfolios a

Article Snippet: CapitalBio , Joint R&D and commercialization programs in China with Affymetrix (Santa Clara, CA, USA) for gene expression profiling and genotyping services (including the development of an advanced GeneChip-compatible point-of-care system) using Affymetrix's photolithographically synthesized oligonucleotide chip technology. Provided non-exclusive rights to Alpha Innotech (San Leandro, CA, USA) for marketing of CapitalBio's microarray laser scanner. Deal to undertake joint product development, manufacturing in China, technology transfer, services and products mutual representation with BioTools (Madrid). Deal to distribute Becton Dickinson (Franklin Lakes, NJ, USA) products in China. Exclusive rights to distribute certain products from Enzo Biochem (New York), BioMachines (Research Triangle Park, NC, USA), Aviva Systems Biology (San Diego), Macherey-Nagel (Düren, Germany), Advalytix (Brunnthal, Germany) in China. Exclusive rights to MediBic (Tokyo) to market CapitalBio's pharmacogenomic services in Japan. Exclusive rights to distribute certain CapitalBio products given to Greenmate Biotech (Seoul, Korea) in Korea, FK Biotec (Port Alegre, Brazil) in Brazil and VitroLab (Istanbul, Turkey) in Turkey. Nonexclusive distribution rights to certain CapitalBio products provided to TechnoConcept (New Delhi, India) and Viswagen Biotech (Kerala, India) in India and Australian Biosearch (Karrinyup, Australia) in Australia..

Techniques: Recombinant, Produced, Expressing, Enzyme-linked Immunosorbent Assay, Diagnostic Assay, Sandwich ELISA, Marker, Incubation, Cell Culture, Microarray, Software, Immunoprecipitation, Injection, Functional Assay, Calcium Assay, Clone Assay, Hybridization, Immunohistochemistry, Transgenic Assay, Knock-Out, Sequencing, Real-time Polymerase Chain Reaction, Genetically Modified, Histone Deacetylase Assay, In Vivo, Modification, Plasmid Preparation, Isolation, Mutagenesis, In Situ Hybridization, DNA Sequencing, Animal Model

Journal: Nature Biotechnology

Article Title: Chinese health biotech and the billion-patient market

doi: 10.1038/nbt0108-37

Figure Lengend Snippet: Collaborations/partnerships between companies interviewed and foreign entities

Article Snippet: CapitalBio , Joint R&D and commercialization programs in China with Affymetrix (Santa Clara, CA, USA) for gene expression profiling and genotyping services (including the development of an advanced GeneChip-compatible point-of-care system) using Affymetrix's photolithographically synthesized oligonucleotide chip technology. Provided non-exclusive rights to Alpha Innotech (San Leandro, CA, USA) for marketing of CapitalBio's microarray laser scanner. Deal to undertake joint product development, manufacturing in China, technology transfer, services and products mutual representation with BioTools (Madrid). Deal to distribute Becton Dickinson (Franklin Lakes, NJ, USA) products in China. Exclusive rights to distribute certain products from Enzo Biochem (New York), BioMachines (Research Triangle Park, NC, USA), Aviva Systems Biology (San Diego), Macherey-Nagel (Düren, Germany), Advalytix (Brunnthal, Germany) in China. Exclusive rights to MediBic (Tokyo) to market CapitalBio's pharmacogenomic services in Japan. Exclusive rights to distribute certain CapitalBio products given to Greenmate Biotech (Seoul, Korea) in Korea, FK Biotec (Port Alegre, Brazil) in Brazil and VitroLab (Istanbul, Turkey) in Turkey. Nonexclusive distribution rights to certain CapitalBio products provided to TechnoConcept (New Delhi, India) and Viswagen Biotech (Kerala, India) in India and Australian Biosearch (Karrinyup, Australia) in Australia..

Techniques: Expressing, Synthesized, Microarray, Functional Assay, Western Blot, Luminex, Histone Deacetylase Assay, Software

Journal: The Journal of Lipid Research

Article Title: Prediction of PPAR- ligand-mediated physiological changes using gene expression profiles

doi: 10.1194/jlr.d300239-jlr200

Figure Lengend Snippet: Fig. 4. Relationship between regulated target genes and the relative drug peroxisome proliferator-acti- vated receptor- (PPAR-) efficacy. A: Comparison of quantitative expression levels as measured in microar- rays and Northern blot analysis and the relative PPAR- efficacies of the tested compounds using linear regres- sion analysis. Fold regulations as calculated in Table 2 were used for the microarray data, whereas signal in- tensities for the genes in Northern blots were col- lected using a PhosphorImager and normalized to the signals for ribosomal phosphoprotein 36B4. For apoli- poprotein C-III (apoC-III), the log fold change was used because this gene is downregulated and its ex- pression ratios lie between 1 and 0. B: Northern blots showing the expression of peroxisomal enoyl-CoA:hy- drotase-3-hydroxyacyl-CoA bifunctional enzyme (bi- functional enzyme), apoC-III, and ribosomal phos- phoprotein 36B4.

Article Snippet: The slide was scanned in a Gen. III microarray laser scanner (Molecular Dynamics).

Techniques: Comparison, Expressing, Northern Blot, Microarray, Functional Assay